Could It Be Your Genes?
Gene
Function/Association
Associated Symptoms
MTHFR (C677T)
🧬 Folate metabolism, homocysteine levels
⚡ Fatigue, ❤️ cardiovascular risk, 😔 depression, 🫀 heart disease, 🧠 stroke, 🤰 miscarriage
MTHFR (A1298C)
🧠 Neurotransmitter synthesis
😟 Anxiety, 😞 mood issues, 🧠 neurotransmitter imbalance
COMT
⚡ Dopamine metabolism, anxiety
😰 Stress intolerance, 😡 irritability
APOE
🧠 Alzheimer's risk, lipid metabolism
🧓 Higher Alzheimer's risk, 🧠 memory loss
VDR
☀️ Vitamin D receptor function
🛡️ Low vitamin D levels, weaker immune response
FUT2
🦠 Gut microbiome, B12 absorption
🍽️ Digestive issues, 💊 low B12 levels, 🤧 higher infection risk
IL6
🔥 Inflammation, autoimmunity
🛡️ Reduced inflammation, potentially lower autoimmune risk
TNF
🔥 Inflammation, TNF-alpha expression
🔥 Higher inflammation, 🦠 autoimmune conditions risk
GSTT1
🧹 Detoxification, oxidative stress
🧹 Reduced detox ability, ⚡ higher oxidative stress
GSTM1
🧹 Detoxification, oxidative stress
🧹 Reduced detox ability, ⚡ higher oxidative stress
SOD2
🔋 Mitochondrial antioxidant enzyme
🔋 Higher oxidative stress, 🧬 mitochondrial dysfunction
MAO-A
🧠 Serotonin/dopamine metabolism
🎭 Higher serotonin/dopamine levels, 😵 mood swings, 😠 irritability
HLA-DRB1
🛡️ Multiple sclerosis risk
🛡️ Increased multiple sclerosis risk, autoimmunity
IL2RA
🛡️ Immune regulation
🛡️ Immune dysregulation, autoimmunity risk
IL7R
🛡️ T cell signaling
🛡️ T-cell dysfunction, possible immune issues
TCN2
💊 Vitamin B12 transport
💊 Low B12 levels, ⚡ fatigue, 🧠 anemia
ACE
❤️ Cardiovascular risk
❤️ High blood pressure, 🫀 cardiovascular issues
NOS3
💓 Vascular function
💓 Poor vascular function, ❤️ cardiovascular risk
DAO
🧪 Histamine degradation
🤧 Histamine intolerance (hives, migraines, GI issues)
HNMT
🧪 Histamine metabolism
🤕 Histamine intolerance (headaches, flushing, rashes)
MAOA
🧠 Mood, aggression
😡 Mood disorders (depression, aggression), 🧠 neurotransmitter imbalance
MAOA (Fast)
🧠 Low serotonin, dopamine
😐 Lower neurotransmitters, 😔 depression risk
MAOB
🧠 Dopamine breakdown
😟 Mood disorders (dopamine imbalance)
ADRA2A
🏃 ADHD, impulsivity
🏃 ADHD symptoms, 🧠 impulsivity
SLC6A4
🧠 Serotonin transport
😢 Higher risk of depression, 😟 anxiety
BDNF
🌱 Neuronal growth
🧠 Reduced neuroplasticity, 🌱 memory issues
DRD2
🎯 Dopamine receptor
😒 Dopamine deficiency symptoms (apathy, addiction tendencies)
DRD4
🎯 Dopamine receptor
🏃 ADHD symptoms, 🎯 novelty-seeking behavior
HTR2A
🧠 Serotonin receptor
😢 Mood disorders (depression, low serotonin activity)
COMT (Slow)
⚡ Estrogen, dopamine metabolism
😰 Anxiety, 🧬 estrogen sensitivity, ⚡ stress intolerance
COMT (Fast)
⚡ Estrogen, dopamine metabolism
😐 Low dopamine, ⚡ low stress resilience, emotional detachment, 😑 difficulty feeling pleasure
